Design & Optimization of Granulation & Compaction Processes for Enhanced Product Performance
Nashville, TN • December 10-12, 2014
This granulation/compaction workshop is an intense course drawing heavily on the interaction between powder properties and unit-operations, covering a variety of granulation and compaction processes as well as formulation techniques. The course emphasizes the marriage between formulation properties, characterization techniques, and engineering scale-up in controlling granule/compact quality. The workshop should be of interest to those involved in powder and pharmaceutical processing or formulation efforts for which granule and compact properties are critical. Typical participants include those from pharmaceutical processing, excipient and chemical manufacture, food and consumer product production, and a variety of advanced material processes.
Registration closes: November 17, 2014
Workshop navigation links below or to left:
Upcoming courses
Course venue
Supporting vendors
Previous course participants
Course schedule
Fees, registration details, & contact information
Instructor
Related reference monographs
Consulting services
Contacts:
Registration, lodging & course content questions should be directed to: courses@powdernotes.com • Registration: 615.469.1342 • Fax: 240.524.8482
Additional details regarding conference center can be obtained at: www.evinsmill.com , Tel: 615.269.3740
Downloads:
Registration form: Registration form
Complete syllabus: E&G Powder School Syllabus
Course venue
Course content will include principles of granulation and compaction; demonstrations of key agglomeration rate process phenomena (wetting, nucleation, granule growth and densification, granule breakage, and forming processes on compaction); design, scale-up & operation of various granulation processes and compaction techniques (fluid-beds, mixers, pans, tabletting, roll pressing, and extrusion). Interactions between formulation properties and process equipment are particularly emphasized in the course. Characterization techniques relevant to granulation and compaction are discussed, including IGC, wet mass rheology and power, permeabilty characterization, fracture testing, Heistand and Heckel compaction testing, particle sizing, NIR chemical imaging, and effusivity. Presentations of participant case studies and pre-course characterization of samples are also offered; contact us directly for further details. This course is based on latest advancements in size-enlargement theory based on the work of Dr. Ennis and colleagues as highlighted in Section 21: Solids Processing, Perry's Chemical Engineers' Handbook, 8th Ed, 2006; “The Science and Engineering of Granulation Processes,” Kluwer Academic Press, 2004; and “Theory of Granulation: An Engineering Perspective,” in Handbook of Pharmaceutical Granulation Technology, 2nd Ed., Marcel Dekker, 2005.
For questions & registration materials, please contact:
E&G Associates, courses@powdernotes.com
Tel: (615) 591-7510 • Fax: (240) 524-8482
Previous course participants
Abbott, Actavis, Albemarle, Alkermes, Amgen, Anderson Co., Astra Zeneca, Biovail Technologies, Bristol-Myers Squibb, Boehringer-Ingelheim, Cabot, Dow, DuPont, Duracell, Eli Lilly & Co., Fauldings, FDA, FMC, Johnson & Johnson, Kodak, Kohler, InHale, Merck & Co., Mankind, Niro, Noveon, Novartis, Novopharm, Novozymes, PCS Phosphate, Pfizer, Pharmacia, Phelps Dodge, Procter & Gamble, Glatt Air, Glaxo Smith Kline, Roxane, Schering-Plough, Shire Pharmaceutical, Searle, Teva Pharmaceuticals, Transform Pharmaceuticals, Tyco Healthcare, Pharmacia, USP, US Steel, Vector, Warner Chilcott, Watson Pharmaceuticals, Wyeth, Wright Industries, & Xerox.
Course schedule
Evening arrival:
Arrival. Check-in 4:00 PM.
Reception & hors d'oeuvres 6:30 PM.
Dinner 7:30 PM.
Introductory evening presentation
Day 1: |
|
7:00 AM |
Breakfast |
8:00 AM |
Morning Lecture: |
12:00 |
Lunch |
1:00 PM |
Afternoon Lecture: |
4:00 |
Afternoon Break |
5:30 |
Dinner |
7:00 PM |
Evening Session: Shear cell & other characterization access for client samples. Offered on first come/first serve basis w/prior arrangements.(Requires prior MSDS review & approval with E&G Associates.) |
8:30 |
Evening hors d'oeuvres & social time |
Day 2: |
|
7:00 AM |
Breakfast |
8:00 AM |
Morning Lecture: |
12:00 |
Lunch |
1:00 PM |
Afternoon Lecture: |
4:00 |
Afternoon Break |
5:30 |
Dinner |
7:00 PM |
Evening Session: Shear cell access for client samples. Offered on first come/first serve basis w/prior arrangements.(Requires prior MSDS review & approval with E&G Associates.) |
8:30 |
Evening hors d'oeuvres & social time |
Day 3: |
|
7:00 AM |
Breakfast |
8:00 AM |
Morning Lecture: |
12:00 |
Lunch |
1:00 PM |
Afternoon Lecture: |
3:00 PM |
Course conclusion |
Supporting characterization vendors:
(Previous presentations. Check back for final program.)
"Study of Top- & Bottom-Spray Fluid Bed Granulation Processes Using In-Line Particle Size Measurement"
GEA: Niro Pharma Systems, Inc., Andrew Birkmire
www.niroinc.com • apb@niroinc.com
"High Shear Granulation- Troubleshooting & Case Studies"
"Roller Compaction - Process Principles &
Troubleshooting"
Vector Corporation, Inc., Tim Smith
www.vectorcorporation.com • tim.smith@vectorcorporation.com
"In-line Particle Size Measurement"
Helos™ laser diffraction demonstrations
Sympatec, Inc., Steve Morosky
www.sympatec.com • smorosky@sympatec.com
"Why measure engineering based material functions?
Perspectives drawn from powder technology practice"
iShear™ flow cell measurements
E&G Associates, Inc., Bryan Ennis, President
www.powdernotes.com • bryan.ennis@powdernotes.com
Solidsizer™ imaging demonstrations
J.M.Canty, Inc.
www.jmcanty.com • todc@jmcanty.com
Fees and registration details
Please note that registration is limited to 15 participants per course date. Course is also offered at regional locations on demand. Registation fee may be waived for outstanding students, with discretionary academic discounts for university staff. Direct requests to: scholarship@powdernotes.com.
Course fees: $1,850 + accommodations.
Registration form: Registration form
Complete syllabus: E&G Powder School Syllabus
Registration closes: November 17, 2014
Registration, lodging & course content questions should be directed to: courses@powdernotes.com • Registration: 615.469.1342 • Fax: 240.524.8482
Additional details regarding conference center can be obtained at: www.evinsmill.com , Tel: 615.269.3740
Instructors
This course is led by Dr. Bryan Ennis, Section Editor, Section 19: Solids-Solids Processing, 8th Ed. (2006), and Section 20: Size Reduction and Size Enlargement (w/Powder Mechanics & Compaction), 7th Ed., 1997, Perry's Chemical Engineers' Handbook, McGraw Hill; The Science and Engineering of Granulation Processes, Kluwer Academic Press, 2004, and Theory of Granulation: An Engineering Perspective, in Handbook of Pharmaceutical Granulation Technology, 3rd Ed., Mercel-Dekker, 2008. He also writes the Agglomeration Advisor column of Powder & Bulk Engineering. www.powderbulk.com. Dr. Ennis has consulted for nearly 100 clients – most Fortune 500 companies – including all major US pharmaceutical companies. He is a manufacturing consultant to the US Food and Drug Administration. He previously led granulation research & powder handling programs of the Particle Science & Technology Center of DuPont Engineering, served as an Adjunct Professor of Vanderbilt University, and is a faculty member of Chemical Engineering of the University of Tennessee at Chattangooga. He received his B.S. (Chemical Engineering) from Rensselaer Polytechnic Institute & Ph.D. from The City College of New York. Dr. Ennis is a founder and previous Technical Vice-Chair of the Particle Technology Forum (PTF) and previous Chair of the Powder Technology Programming Group of the American Institute of Chemical Engineering (AIChE). His honors include two national awards from AIChE for service to the profession and founding of the PTF, previous member of the International Fine Particle Research Institute, Deutscher Akademischer Austausch Dienst Award (Germany), Stanley Katz Memorial Award (City College of NY), and Visiting Research Fellow of Delft Technische Hogeschool (Netherlands). Dr. Ennis runs several continuing education courses in powder flow & handling, powder characterization, and granulation & compaction. He is also founder of iPowder Systems, an instrumentation firm specializing in mechanical property and surface characterization of powders.
Jim Davis is a Principal Consultant to E&G Associates, and President of Powder Processing Solutions LLC. As a previous solids handling technical leader with Procter & Gamble, he has 26 years of experience in the optimization, design & startup of powder processing/material handling systems, spanning over 20 countries and 4 continents. He offers many practical, unique insights for resolving difficult processing problems, and for minimizing design and development costs, from his experience in developing low cost systems for low income, third world markets. Jim holds a BSc in Mechanical Engineering degree from the University of Cincinnati, and a Professional Engineer’s license from the State of Ohio. He has served on the Executive Committee of the International Fine Particle Research Institute, as Chairman of the ASTM subcommittee on Powder and Bulk Systems, as Chairman of the Powder Handling subcommittee of the Particle Technology Forum of AIChE, and sits on the industrial advisory board for the trade journal Powder & Bulk Engineering. www.powderbulk.com.
Related reference monographs
Please email us a request for details on the following publications:
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Section 21: Solids-Solids Processing (Solids Handling), Perry's Chemical Engineers' Handbook, Sect.Ed. (Bryan Ennis), 8th ed., 2006. McGraw Hill (In preparation). Includes latest section of granulation and compaction.
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Section 20: Size Enlargement & Size Reduction, Perry's Chemical Engineers' Handbook, (Size Enlargment/Powder Mechanics, Ennis & Litster), 7th ed., 1994. McGraw Hill.
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Theory of Granulation: An Engineering Perspective, in Handbook of Pharmaceutical Granulation, 2nd Ed., B. Ennis, (Parikh ed.) Mercel-Dekker, 2005
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The Science & Engineering of Granulation Processes, Litster & Ennis, Kluwer Academic, 2004
Email request for more information:Book request
Consulting services
E&G Associates has considerable consulting experience in support of granulation and compaction processes, as well as surrounding material handling issues, relying heavily on powder characterization of relevant formulation properties. Contact directly if such needs arise.
For more information see: E&G Associates
Email us for further inquiries: Email